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Folding time dependence of the motions of a molecular motor diluted inside an amorphous medium

机译:折叠的分子运动的运动的折叠时间依赖性   在无定形介质中

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摘要

We investigate the dependence of the displacements of a molecular motorembedded inside a glassy material on its folding characteristic time. Weobserve two different time regimes. For slow foldings (regime I) the diffusionevolves very slowly with the folding time, while for rapid foldings (regime II)the diffusion increases strongly with the folding time suggesting two differentphysical mechanisms. We find that in regime I the motor displacement during thefolding process is counteracted by a reverse displacement during the unfolding,while in regime II this counteraction is much weaker. We notice that regime Ibehavior is reminiscent of the scallop theorem that holds for larger motors ina continuous medium. We find that the difference in the efficiency of the motormotion explains most of the observed difference between the two regimes. Forfast foldings the motor trajectories differ significantly from the oppositetrajectories induced by the following unfolding process, resulting in a moreefficient global motion than for slow foldings. This result agrees with thefluctuation theorems expectation for time reversal mechanisms. In agreementwith the fluctuation theorems we find that the motors are unexpectedly moreefficient when they are generating more entropy, a result that can be used toincrease dramatically the motor motion.
机译:我们研究了嵌入玻璃态材料中的分子运动的位移对其折叠特征时间的依赖性。我们观察两个不同的时间范围。对于慢速折叠(方案I),扩散随折叠时间的变化非常缓慢,而对于快速折叠(方案II),扩散随折叠时间的增加而强烈增加,这提示了两种不同的物理机制。我们发现,在方案I中,折叠过程中的马达位移被展开过程中的反向位移抵消,而在方案II中,这种抵抗力要弱得多。我们注意到,Ibehavior机制让人想起了扇贝定理,该扇贝定理适用于连续介质中的大型电机。我们发现,运动效率的差异解释了两种方案之间大多数观察到的差异。对于快速折叠,电机轨迹与随后的展开过程所引起的相反轨迹明显不同,因此与慢速折叠相比,全局运动效率更高。这一结果与对时间反转机制的波动定理的期望吻合。与波动定理一致,我们发现当电动机产生更大的熵时,电动机的效率出乎意料地更高,该结果可用于极大地增加电动机的运动。

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